SARS-CoV-2 Lambda (Peru) Strain Analysis
WHO added a SARS-CoV-2 strain named ‘Lambda’ that was first detected in August 2020 in Peru. This Peru variant has been reported in over 29 countries. On June 14, the WHO classified it as a global variant of interest due to an elevated prevalence in South America. The spike protein mutations are complicated, including G75V, D253N, D614G, L452Q, F490S, T76I, T859N, D1153Yand amino acid 246-252 (RSYLTPG) deletion.
Phylogenetic analysis of 180 sequences of SARS-CoV-2 lambda variants.
First evidence showing RNA recombination accelerates
SARS-CoV-2 viral evolution in Diamond Princess shipboard
SARS-CoV-2 viral evolution in Diamond Princess shipboard
Recent publication (Bulletin of the World Health Organization; April 5, 2020):
"Faster de novo mutation of SARS-CoV-2 in shipboard quarantine."
https://www.who.int/bulletin/online_first/20-255752.pdf
"Faster de novo mutation of SARS-CoV-2 in shipboard quarantine."
https://www.who.int/bulletin/online_first/20-255752.pdf
First evidence of unique mutations in stem-loop II motif (s2m)
in Australia SARS-CoV-2
in Australia SARS-CoV-2
(A) Deletions and mutations in the COVID-19 s2m RNA motif based on the three-dimensional crystal structure of SARS virus. G19 mutation of Australian SARS-CoV-2 is shown with purple color. Asterisks label RNA recombination site. (B) Schematic representation of the s2m RNA secondary structure of SARS virus, with tertiary structural interactions indicated as long range contacts. U9 and G35 are substituted by C and U, respectively, in SARS-CoV-2 virus.
Recent publication in Medical Journal of Australia (May 15, 2020) onlinelibrary.wiley.com/doi/10.5694/mja2.50657
First case report of a COVID-19 patient in Kaohsiung City, Taiwan
(A) Alignment of ORF3a protein of 2019-nCoV Hu-1 and SARS coronavirus. Transmembrane and Golgi localization motif are underlined in orange and purple, respectively. O-glycosylation sites are in green. E191G and G251V mutations (red) are shown in Taiwan and US-CA2, Sweden01, Italy-isl isolates. (C) Schematic representation of 2019-nCoV ORF3a protein. Both E191G and G251V mutations are in cytoplasmic region of Orf3a. (C) Mutation in tryptophan 913 (W913) is located in the thumb domain of RdRp. Structure of viral RNA-dependent RNA polymerase (RdRp) is based on SARS (Kirchdoerfer et al. 1.Nat Commun 2019; 10: 2342.)
Recent publication in Access Microbiology (April 1, 2020) www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000133
We Create:
Bio-pesticides, bio-detergents, bio-dyes for plant cures, soil reclamation and drug development
Bacteriophages
In February 2020, Auxergen received a Notice of Allowance for it's first family of biopesticides: CitriPhage / XanthaPhage: engineered bacteriophages which are designed to inhibit and destroy Xanthamonas citri., and more than two dozen other sub species of Xanthamonas bacteria, including citrus canker, rice blight and diseases of banana, soybean, cassava, wheat, pepper, and brassica vegetable (cabbage, broccoli, etc.) crops. This is good news for farmers who can call on a new, non-chemical option to improve crop health, quality and yields.
Auxergen's Agricultural Biotechnology division is located at The Institute of Marine and Environmental Technology, part of the University of Maryland's Harbor Launch Incubator Program
